Our ability to discover effective drug combinations is limited, in part by insufficient understanding of how the transcriptional response of two monotherapies results in that of their combination.We analyzed matched Hydrating Serum time course RNAseq profiling of cells treated with single drugs and their combinations and found that the transcriptio
Cas12a, also known as Cpf1, is a highly versatile CRISPR-Cas enzyme that has been widely used in genome editing.Unlike its well-known counterpart, Cas9, Cas12a has unique features that make it a highly efficient genome editing tool at AT-rich genomic regions.To enrich the CRISPR-Cas12a plant genome editing toolbox, we explored 17 novel Cas12a ortho
In recent years, research on detecting malicious executable and linkable format (ELF) files based on deep learning had made significant progress.At the same time, adversarial attacks on models had also gained widespread attention.Attackers could generate Sodas adversarial examples to mislead neural networks, causing malicious software to be misclas
In this article the possibilities of the use of place names in the literary texts of the two languages of different systems are grouped.Here the fact is proved that writers treat individually real place names.In the Azerbaijani and English literary texts real place names are used for two reasons.Firstly, to persuade the reader that the events happe
BACKGROUND: Severe burn injury results in the loss of intestinal barrier function, however, the underlying mechanism remains unclear.Myosin light chain (MLC) phosphorylation mediated by MLC kinase (MLCK) is critical to the pathophysiological regulation of intestinal barrier function.We hypothesized that the MLCK-dependent MLC phosphorylation mediat